There were no side effects from silymarin.4 The dosage has not been established in pediatric patients. The typical silymarin dosage used in most studies was ~420 mg/day divided into 2 or 3 doses. Common side effects of Silymarin : Abdominal bloating, diarrhea, flatulence, loss of appetite, nausea and stomach upset. Brief stomach upset and mild allergies, but no serious side effects, have been reported. Beneficial in a number of diseases involving liver disease; Direction for use/Dosage: – Take as directed by the physician Phytosome technology improves the bioavailability of silybin as it is complexed with phosphatidylcholine. Generic Name : Silymarin Pronunciation : SILL-ee-MAR-inn Latest prescription information about Silymarin. The recommended dose is 140 mg 2-3 timesday. The four-year survival rate was 58 percent in the silymarin group and 39 percent in the placebo group. In dogs given oral citicoline 1.5 g/kg daily for 6 months, no biochemical, neurological, or histological toxicity was found.1. What is the dose of Legalon® (Silymarin) for a child? 70mg-capsule: 2 capsule/time x 3 times a day. What is the dose of Legalon® (Silymarin) for an adult? Search drug, interactions and image information in China, Hong Kong, Taiwan, Malaysia, Singapore, Philippines, Vietnam, Thailand, Indonesia, India & USA It may be unsafe for your child. Silymarin promotes liver cell protein synthesis and decreases the oxidation of glutathione. Silymarin may intensify the effects of drugs that decrease blood sugar levels (hypoglycemic drugs). References. Side Effects & Safety When taken by mouth: N-acetyl cysteine is LIKELY SAFE for most adults. Click here for full details on all the markets covered. Subjects received 140 mg silymarin three times a day for 41 months. These results have been established by experimental and clinical trials. The IV median lethal dose in rodents was suggested to be around 4 g/kg. The reduced death rate among those taking silymarin was most pronounced in the alcoholic cirrhosis subgroup. In people with liver disease, the typical dosage was higher, around 1.3 g/day of the standardized for 6 – 8 weeks (divided into 3 doses during the day). 140mg-capsule: 1 capsule/time x 3 times a day. 1. Silymarin is a fruit extract from the plant milk thistle that is claimed to be a free radical scavenger and to have hepatoprotectant properties; it has been used in various liver … A 30-day study in rats found no toxicity at 150 mg/kg/day. The silymarin exerts membrane-stabilizing and antioxidant activity, it promotes hepatocyte regeneration; furthermore it reduces the inflammatory reaction, and inhibits the fibrogenesis in the liver. It can cause nausea, vomiting, and diarrhea or constipation. How should Silymarin be used: It comes as a tablet, capsule, and syrup to take by mouth, with food. 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